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Helse Sør-øst RHF

Postdoctoral researcher

Offentlig forvaltning

Post-doc position on the regulation of cellular fate and differentiation by SUMO
We announce a full-time postdoctoral position (36 months, starting March 2020) in the group of Dr. Pierre Chymkowitch, Department of Microbiology, Oslo University Hospital, Oslo, Norway. The Dept. of Microbiology is a well-equipped internationally competitive research environment. Furthermore, our group has an extensive collaboration network nationally and internationally. Finally, our research is interdisciplinary and has significant funding through the Research Council of Norway, Helse Sør.

Project summary
Obesity is a serious global health problem that increases the risk for type 2 diabetes and other related diseases like cancer. Unfortunately, current treatments often result in metabolism damage without inducing weight loss. There is thus a clear need for antiobese drugs that improve metabolism and induce weight loss. We have data suggesting that the small ubiquitin-like modifier Sumo is deeply involved in the regulation of adipose tissue function and identity. This research project thus seeks to address the role of Sumo-mediated gene control during adipocyte differentiation at the chromatin level, with a primary focus on human and mouse adipose stem cells.
The candidate should ideally match the following profile
  • Owning a Ph.D. in Biology 
  • Extensive laboratory experience in molecular biology, cell biology and biochemistry 
  • Experience in ChIP/ChIP-seq, RNA-seq, qPCR 
  • Experience in microscopy  
  • Programming skills would be a plus 
  • Experience with proteomics would be a plus 
  • Experience with NGS Bioinformatics would be a plus 
  • Full professional proficiency in English    
Personal skills
  • Enthusiasm and curiosity
  • Willingness to engage into discussion on how’s and why’s
  • Drive and commitment to carry out experiments to the end
We offer
  • A dynamic working environment in the research section at Rikshospitalet.
  • A very international, young and stimulating work place.