A 3-year engagement for a postdoc position is available at the Dept. of Immunology and Transfusion medicine at Oslo University Hospital, Rikshospitalet. The position will provide an opportunity to pursue research on the mechanisms regulating B cell receptor signaling in patients with various B cell malignancies.

We seek a highly motivated, precise and energetic person for a post-doctoral researcher position. Our laboratory is focused on understanding B cell receptor signaling in hematological malignancies, as well as immunodeficiencies and autoimmunity. Our work include ex vivo activation and differentiation studies of healthy and malignant B cells as well as in vivo murine xenotransplantation models. We work closely with clinicians, and studies also involve the use of live-cell specimens from patients with B cell malignancies immunodeficiencies and autoimmune diseases.

Research infrastructure includes access to several core facilities, including flow cytometry, confocal microscopy, non-invasive small-animal imaging and proteomics. The position is associated with a grant from HSØ (2026096) Controlling malignant B cell fitness by CD43-targeting of the unfolded protein response.

About the position:
The post-doctoral researcher will carry out a project to decipher the molecular and cellular aspects of B cell receptor signalling in healthy individuals as well as in patients with B cell haematological malignancies with a key emphasis on the role of CD43 as a regulator of the unfolded protein response. Techniques involved in these projects are listed under Key Tasks. 

Oslo University Hospital is a workplace with great diversity. We believe this is crucial for solving our tasks in the best possible way. We want this diversity to be reflected among the applicants for our positions, and we encourage all qualified candidates, regardless of background, to apply!

Kvalifikasjoner:

• Norwegian PhD degree or equivalent.
  
• A high degree of independence in performing experiments and refining the experimental approach is required.
• Candidates must have good experience with flow cytometry (including spectral flow), molecular biology techniques.
• A background in B cell biology and previous research within B cell malignancies (B cell acute lymphoblastic leukemia) and competence in RNAseq analyses is an advantage.
  

Personlige egenskaper:

• Application letter, including research interests and the motivations for applying for this position.
  
• CV summarizing education, positions held, details of academic work and other qualifying activities.
  
• Copies of educational certificates and transcripts of records.

The application letter and CV should be in English or in a Scandinavian language. All other documents could be in English, German, French, Italian or a Scandinavian language. 

Vi tilbyr:

• A stimulating, active and attractive working environment.
  
• Involvement in a versatile and ambitious set of research projects.
  
• Salary according to guidelines from the South-Eastern Norway Regional Health Authority.
  
• Opportunities and support for career development.
  
• Possibility of extension.