Detaljer


Scientist

A 10 months position as researcher is available at the Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital. The position is associated with the research group of Karl-Johan Malmberg.  

The main focus of the group is to study the molecular and cellular basis for NK differentiation and repertoire formation in health and disease. A key focus is to gain insights into how killer cell immunoglobulin-like receptors (KIRs) influence the function of human NK cells. KIRs are HLA class I binding receptors with important functions in reproduction, immunity to infections, and in cell therapy against cancer. We examine the dynamic shaping of human NK cell repertoires at homeostasis, during viral infection, tumor transformation and following stem cell transplantation. We are also seeking to implement new insights into the adaptive-like behavior of NK cells in the next generation of NK cell-based immunotherapy for patients with refractory or relapsing malignancies.The group makes extensive use of advanced multicolor flowcytometry, CyTOF, molecular biology methods, cellular assays, advanced imaging and initiates clinical studies with cell therapy towards hematological cancers.
Home page: https://www.ous-research.no/malmberg/

Tasks
The current project takes advantage of our knowledge from NK cells to study cellular mechanisms regulating functional tuning of human T cells. We are looking for an experienced T cell researcher with previous expertise in innate lymphoid cells as well as expertise on high throughput analysis of T-cell repertoires using NGS.

Qualifications
Suitable candidates must  have a PhD in immunology/cell biology/molecular biology or related field with extensive research experience after PhD.
Project relevant PhD and immunological/medical knowledge are considered strong advantages.


Personal skills
We are looking for a highly motivated candidate with a strong interest in scientific research and excellent teamwork skills. The successful candidate will have an interest in solving biological problems and the ability to design, plan, and interpret original experiments in an independent and innovative manner. Previous experience from research visits/post-docs at leading international institutions and experience with supervision of students are considered an advantage.  

The application should include
A one-page statement of motivation and research interests
CV (summarizing education, positions and academic work)
List of publications and academic work
Transcripts of university diplomas   
 
Names and contact details of 2-3 referees (name, relation to candidate, e-mail and phone number)