A 10 months position as researcher is available at the Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital. The position is associated with the research group of Karl-Johan Malmberg.
The main focus of the group is to study the molecular and cellular basis for NK differentiation and repertoire formation in health and disease. A key focus is to gain insights into how killer cell immunoglobulin-like receptors (KIRs) influence the function of human NK cells. KIRs are HLA class I binding receptors with important functions in reproduction, immunity to infections, and in cell therapy against cancer. We examine the dynamic shaping of human NK cell repertoires at homeostasis, during viral infection, tumor transformation and following stem cell transplantation. We are also seeking to implement new insights into the adaptive-like behavior of NK cells in the next generation of NK cell-based immunotherapy for patients with refractory or relapsing malignancies.The group makes extensive use of advanced multicolor flowcytometry, CyTOF, molecular biology methods, cellular assays, advanced imaging and initiates clinical studies with cell therapy towards hematological cancers.
Home page: https://www.ous-research.no/malmberg/
Project relevant PhD and immunological/medical knowledge are considered strong advantages.
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