At the Stem Cells, Ageing and Cancer team, Centre of Excellence CRESCO and Section for Microbiology, Oslo University Hospital, lead by Lorena Arranz, we have a full-time temporary position for three years as a researcher.

The research vision of the Arranz team is the identification of novel and efficient therapeutic targets of clinical interest with the potential to improve survival rates and quality of life in patients. We conduct research and innovation in myeloid blood cancers with a particular focus on targeting stem cells and their niches as potential therapeutic strategies. We are seeking a highly motivated scientist with extensive experience in hematology research and immediate availability, to contribute to a project aiming at providing insights on how the sympathetic nervous system is involved in malignant hematopoiesis and could be targeted therapeutically. The position is part of the newly funded project “NEUROTARGET” supported by Helse-Sør-Øst, which aims at using the neural components of the stem cell niche as therapy in a subset of patients with myeloid cancers. The successful candidate will work at the interface of translational and clinical research, using state-of the art in vivo models and patient materials.

“NEUROTARGET” aims to dissect how newly identified genetic variants involved in the sympathetic nervous system function are enriched in patients with myeloid cancers, their impact on hematopoiesis, and their potential as targets for therapeutic strategies. A central objective is the development of relevant mouse models, to characterize the pathogenic potential of the variants in vivo and the value of their targeting as therapy in preclinical models. Another important objective involves research with human stem cells and relevant stem cell niche components ex vivo and in vivo. The aim of NEUROTARGET is to provide the scope for a larger project with expected benefit for future care of patients with myeloid cancers.

Oslo University Hospital is a workplace with great diversity. We believe this is crucial to solving our tasks in the best possible way. We are an international team and we want this diversity to be reflected among the applicants for this position. We encourage all qualified candidates to apply.

Kvalifikasjoner:

• PhD in physiopathology or cancer biology.
  
• Extensive documented experience with animal models in the field of hematology and active FELASA C certification are required.
  
• Strong documented interest in myeloid cancer biology and translational research, with at least two high-quality publications as first author in the field.
  
• Documented experience with stem cell transplants in mice is required.
  
• Strong expertise in conventional and spectral flow cytometry method development and data analysis, using BD Fortessa analyzer and Aria sorter, SONY ID7000 analyzer and CYTEK Aurora analyzer is required.
  
• Experience in molecular biology with low input (eg. multiplex cytokine assays, ddPCR, etc) is required.
  
• Experience with confocal microscopy is an advantage.
  
• Strong written and verbal communication skills in English.

Documentation of previous education and experience must be attached to the application, which is submitted via webcruiter by clicking on the link "apply for the position".

Personlige egenskaper:

We are looking for someone:

• Precise and structured.
  
• With good collaboration skills and ability to train others.
• Motivated and hardworking.
  
• That contributes to a good working environment.
  
• That shares our research vision.
  
• That has flexibility to adapt to different working hours when needed.
  
• With immediate availability.

Vi tilbyr:

• A highly collaborative and interdisciplinary research environment.
  
• Access to state-of-the-art technology with a move to Oslo Life Science Building in 2027.
  
• Opportunities to work on biologically and clinically impactful questions.
  
• Strong support for scientific development and career progression.
  
• Good working environment at the professional and social levels.
  
• Competitive salary according to qualifications.