Position summary:
Oslo University Hospital (OUS) is Norway’s largest biomedical research institution. We are seeking a motivated postdoctoral researcher in a 100 % position for three years, to join a multidisciplinary team investigating the dynamic evolution of colorectal cancer (CRC) from primary tumors to liver metastases. This position will focus on dissecting molecular and phenotypic differences between primary tumors and liver metastases using patient-derived organoids (PDOs), advanced live-cell imaging, and spatial transcriptomics. By integrating these cutting-edge methodologies with clinical data from the SYLMET trial (simultaneous vs. staged resection of CRC liver metastases), the project aims to uncover mechanisms of metastatic adaptation and identify biomarkers for personalized therapy.

Research Environment:
Project Leader: Stig Ove Bøe, PhD (Head of the Cell and Tissue Dynamics Group, OUS). Bøe’s research team focus on microscopy-driven studies of collective cell migration, tissue regeneration, and tumor invasion.
Webpage: OUH - Cell and tissue dynamics (Bøe)

Key Collaborators:
Frode Jahnsen, MD, PhD (Mucosal Immunology and Cancer Research Group, OUS): Expertise in CRC pathology and spatial transcriptomics.
Webpage: OUH - Mucosal Immunology and Cancer Research

Sheraz Yaqub, MD, PhD (Principal Investigator, SYLMET trial, OUS): Clinical studies in colorectal surgery and metastasis management.
Webpage: OUH - Hepatobiliary malignancies

Oslo University Hospital is a workplace with great diversity. We believe this is crucial to solving our tasks in the best possible way. We want this diversity to be reflected among the applicants for our positions, and encourage all qualified candidates, regardless of background, to apply.

Kvalifikasjoner:

• A record of peer-reviewed international publications.
• Experience with advanced cell culture systems such as organoids.
• Experience with advanced microscopy technologies, including spatial and live imaging.
• Computational skills in quantification and statistical analysis of microscopy-based data sets. Knowledge in computer programming tools e.g. Python pr C+.

Personlige egenskaper:

• A supportive and stimulating scientific environment for personal academic development.
  
• Top modern and excellent lab facilities with a wide range of core facilities.
• A three year contract with the possibility for extension.
• Attractive salary according to OUS guidelines, with a full-time contract for three years.
• Access to large, unique datasets and state-of-the-art lab facilities.
• Attractive welfare benefits, a favorable pension plan, and a family-friendly work environment enriched with cultural and outdoor activities in Oslo.

Vi tilbyr:

• Cover Letter detailing motivation and research interests.
  
• A recent CV including a complete list of scientific publications.
  
• Copies of educational certificates and grades with explanations of the grading system.
  
• Two to three reference letters with contact details of the referees.
  

Interested candidates should apply online by clicking the link "apply for position" and submit the required documents.

 

Why This Matters:
Liver metastasis drives CRC mortality, yet the functional and molecular shifts enabling metastatic fitness remain poorly understood. By bridging dynamic phenotypes with patient outcomes, this project will uncover mechanisms of therapy resistance and inform precision oncology strategies. Join us to advance both fundamental cancer biology and clinical care for CRC patients.