Two postdoc positions in cancer immuno-gene therapy at Oslo University Hospital

Two senior postdoc positions are available for 2 and 3 years, with possibility for extension, from Nov 15th 2022, in the research group of Dr. Jon Amund Kyte at Dept. of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital (OUH). OUH is Norway’s largest hospital and medical research institution, and is accredited as a Comprehensive Cancer Center by the Organization of European Cancer Institutes. OUH has a particularly strong research profile in cell therapy (www.ous-research.no/strat-cell), a newly established core facility for advanced cell therapy and a proven record in bringing novel immunotherapy ideas from preclinical development into clinical trials. The postdocs will work in teams with other members of the Kyte group at the Dept. of Cancer Immunology. The Kyte group has 14 members with research expertise in immunology, molecular biology and medicine. Dr. Kyte is also Head of the Department for Clinical Cancer Research (www.phase1.no).

Research Description:

The Kyte Group has developed several tumor-targeting chimeric antigen receptors (CARs) and other constructs for T cell therapy. The successful applicants will work on a new project called “CAR360”, for development of personalized CAR T cell therapy countering tumor escape in treatment refractory solid cancers. This includes approaches countering immune suppression and the targeting of multiple antigens and tumor subpopulations. The project will make use of proprietary constructs developed in the group. Most required methods have been established. 

 

Oslo University Hospital is a workplace with great diversity. We believe this is absolutely crucial to solving the tasks required of us. We therefore want this diversity to be reflected among the applicants for our positions and encourage everyone to apply regardless of who you are and what background you have.

Kvalifikasjoner:

• Ph.D. in immunology/molecular biology/cell therapy and a proven record of research, evidenced by successful publishing in scientific journals.
• Strong research background in molecular biology, cellular immunology and animal models, including methods relevant for antibody and CAR T cell research.  

Personlige egenskaper:

• Robust practical skills in immunology and molecular biology, including design and molecular cloning of novel constructs, retroviral work and gene editing, cell culture, flow cytometry, immunohistochemistry and T-cell functional assays.
• Knowledge in development of bi-specific antibodies or CAR /TCR cell therapy is desirable.
• Excellent written and oral communication skills (English)
• Ability to take initiatives and to work independently, as well as in collaborative research efforts.

Vi tilbyr:

• Interesting and high-impact research project, with huge potential for clinical application
• An opportunity to acquire cutting edge knowledge within the hot-topic CAR T and bi-specific antibody therapies
• Full-time two and three-year positions, with possibility for extension
• Salary according to the OUS salary scale
• Favorable pension arrangements
• Attractive welfare arrangements