Understanding the prostate tumor microenvironment with single cells and spatial transcriptomics analyses

About Us:
Join the project group led by Dr. Urbanucci at the Oslo University Hospital, Institute for Cancer Research. The Project Group (www.ous-research.no/urbanucci) operates within the Eivind Hovig research group at the Department of Tumor Biology. Here Dr Urbanucci holds a part time position while he also is affiliated with the Prostate Cancer Research Centre at Tampere University, Finland. Dr Urbanucci´s team focuses on unraveling the complexities of the prostate tumor microenvironment.

Position Overview:
We are seeking a skilled and motivated Postdoctoral Researcher to contribute to ongoing projects involving single-cell and spatial transcriptomics. The successful candidate will work on optimizing protocols for sequencing from cells and clinical tissue. Additionally, they will be involved in cell and molecular biology work, emphasizing the preclinical development of small molecule inhibitors.

Oslo University Hospital is a workplace with great diversity. We believe this is absolutely crucial to solving the tasks required of us. We therefore want this diversity to be reflected among the applicants for our positions and encourage everyone to apply regardless of who you are and what background you have.

Kvalifikasjoner:

• PhD in Molecular/Medical Biotechnology or related field, obtained working in cancer research (experience with prostate cancer research is an advantage).
  
• Strong laboratory skills in genomics, with a focus on molecular biology, functional genomics, and/or cell biology.
  
• Understanding of immunology, DNA repair and radiobiology, biochemistry, genomics experiments, and statistics.
  
• Prior experience in generating experimental omics datasets.
  
• Prior experience in managing/leading complex projects with multiple collaborators.
  
• Ability to work with mice is desirable but not required.
  

Technical Skills:

• Work with tissue (nuclei and single cell work is an advantage) and chromatin-immunoprecipitation, IHC, or immunofluorescence microscopy.
  
• Cell/tissue culture (experience with patient-derived material is advantageous).
  
• RNAi experiments (must have) and drug screening (desirable).
  
• Nucleic acid and protein extraction from tissue and cells.
  
• Western blotting and qPCR.
  
• Flow Cytometry (desirable).
  
• Proficiency in excel, word, endnote, prism, adobe illustrator.
  
• Critical experimental design, Sequencing Library preparation, Knowledge of R and basic computational data analysis .

Personlige egenskaper:

• Proactive, outgoing, team-building.
• Passionate about discovery and interested in Science.
• Willingness to travel.
• High work capacity and productivity
• Able to work independently and in teams.
• Motivated and solution oriented.
• Multidisciplinary communication skills.

Vi tilbyr:

• Temporary employment for two years, renewable based on performance.
  
• Research training, supervision, and the possibility to supervise students.
  
• International and dynamic working environment with opportunities for skill development and growth.
  
• Competitive salary according to qualifications and experience.
  
• Flexible working hours.
   
  How to Apply:
  Applications should be sent through the online system webcruiter and should include a one-page cover letter describing your past accomplishments, research goals, interest and motivation together with recent curriculum vitae (CV) including list of publications (with a note summarizing the role of the candidate in each publication). Please send inquires and reference letters with contact details to: alfonsourbanucci@gmail.com.