About the lab

A 1-year position as engineer is available at the Department of Pathology, Oslo University Hospital, from 1.May 2026 - 30.April 2027. The position will be associated with the ‘breast cancer heterogeneity and oncoimmunology’ project group (https://www.ous-research.no/tekpli) and is financed by the Norwegian Health authorities through the project: "Longitudinal analyses of single cells in breast tumors to characterize and overcome resistance to therapies".

The lab has longstanding collaborations with oncologists at Oslo University Hospital (OUH) and Akershus University Hospital (Ahus) and conducts translational research in numerous clinical trials. Through collaborations with oncologists, we integrate cutting‑edge single‑cell analysis with clinical studies to characterize mechanisms of sensitivity and resistance to standard‑of‑care and investigational breast‑cancer therapies.

The past 3-4 years, we have performed single cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST) on tumor biopsies sampled at different time points of neoadjuvant therapy. Currently, the major focus of the lab is to use single cell technologies to understand which exact cell types / phenotypes are sensitive or resistant to therapies and to characterize how the tumor microenvironment determines tumor behavior and response to cancer therapies. We also maintain an innovative program to analyze, at single‑cell resolution, how epigenetic modifications and enhancer usage contribute to treatment resistance.

Oslo University Hospital is a workplace with great diversity. We believe this is crucial for solving our tasks in the best possible way. We want this diversity to be reflected among the applicants for our positions, and we encourage all qualified candidates, regardless of background, to apply!

Kvalifikasjoner:

We are looking for a highly motivated, well-organized and dynamic person with creative thinking. The ideal candidate has:

• Bachelor in one of the following areas: molecular biology, cell biology or biochemistry
• Working proficiency with standard laboratory procedures
• Experience in biobanking human biopsies and extracted nucleic acids and/or proteins
• Experience in isolating single cells or single nuclei from fresh frozen or FFPE samples (an advantage)
• High intrinsic motivation and strong scientific curiosity
• Excellent oral and written English communication skills
• A proactive, flexible and problem-solving attitude

Personlige egenskaper:

• A full-time contract for one year
• Access to state-of-the-art technologies
• A stimulating international and multidisciplinary research environment where quality, professionalism and team spirit are encouraged
• The opportunity to work on scientifically exceptional, high-impact, state-of-the-art projects
• The chance to be part of a young and dynamic team and to make a meaningful contribution to oncological research
• Rigorous research training and supervision

Vi tilbyr:

All applications must include:

• A cover letter describing your motivation
• A full CV including contact details and a list of publications (if any)
• Transcripts and diplomas for bachelor’s and master’s degrees.
• The names and contact information of 1–2 referees