A three year postdoctoral position to develop and implement bioinformatic methods for long-read RNA sequencing data analysis, is available at Dept. Medical Genetics, section for Research and Development, Oslo University Hospital.

Your research will be part of a translational research project titled “Functional genomics platform for discovery of regulatory genetic variation and mechanisms in immune disorders”.  You will be employed by Oslo University Hospital while the project and your physical working location will be at the Centre for Molecular Medicine Norway (NCMM), the Nordic EMBL Partnership for Molecular Medicine in the Oslo Science Park. NCMM, hosted by the University of Oslo, is an international biomedical research centre, with the overall objective of translating basic medical research into clinical practice.

Saarela group at NCMM is investigating rare and complex immune and haematological diseases by utilizing modern genetic and informatics methods. The aim of the project is to set up a functional genomics platform based on long and short read RNA sequencing and genome editing combined with functional assays of cell models to improve the diagnostic yield and identify novel disease-causing genetic variants for inherited errors of immunity. Your role will be to develop and implement bioinformatic methods to analyse short and long read RNA sequencing as well as genome sequencing data to identify novel genetic causes for inherited immune disorders. You will be a member and working closely with Saarela's Human immune disorder research group (https://www.med.uio.no/ncmm/english/groups/saarela-group/index.html ) and are encouraged to build close collaborations with the other computational biology groups in NCMM, Oslo University Hospital and the other Nordic EMBL Molecular Medicine centres.

The Department of Medical Genetics at Oslo University Hospital is Norway’s largest medical genetics department with over 200 employees. The department is responsible for diagnostics of rare and inherited diseases, and runs a national research infrastructure for high-throughput DNA sequencing at the Norwegian Consortium for Sequencing and Personalized Medicine (www.norseq.org). The research section in the department has 7 research groups (www.ous-research.no/meg/) working in various fields of medical genetics, including genetics, epigenetics, bioinformatics and functional genetics of breast cancer, autoimmune diseases, neurological, cardiovascular and psychiatric disorders. The Saarela group is collaborating with the research section at the department.

Oslo University Hospital is a workplace with great diversity. We believe this is absolutely crucial to solving the tasks required of us. We therefore want this diversity to be reflected among the applicants for our positions and encourage everyone to apply regardless of who you are and what background you have.
 

Kvalifikasjoner:

The successful candidate should:

• hold a PhD degree in bioinformatics, computational biology or genetics (mandatory)
• have proven hands-on experience in NGS and particularly RNA seq analysis
• have at least Python or equivalent programming skills
• have at least two published first-author papers

Previous experience in rare and complex disease genetics and deep learning are considered an advantage.

Personlige egenskaper:

The successful candidate have:

• excellent English oral and written communications skills
• good interpersonal and communication skills 
• ability to work independently as well as within a team
• good problem-solving and analytical skills

Vi tilbyr:

• A full-time contract for three years with possibility for extension, depending on the availability of funding.
• A 6 month trial period will be applied.
• Salary in agreement with the current collective agreement
• A workplace that is an inclusive working life (IA) company
• A stimulating (international, multidisciplinary) research environment where quality, professionalism and team spirit are encouraged.
• The opportunity to be part of a young and dynamic team
• Rigorous research training and supervision
  
  

How to apply

• Please send your application including motivation letter and CV, including list of publications and contact information for two references.
• Please note that all documents must be in English. Foreign applicants are advised to attach an explanation of their University's grading system.
• Please apply via "Apply for position". We do not accept applications by e-mail.

Place of work

Centre for Molecular Medicine Norway (NCMM), the Nordic EMBL Partnership for Molecular Medicine in the Oslo Science Park.
Address: Gaustadalleen 21, 0349 Oslo