A postdoctoral position, financed by Health South-East (HSØ) is available for 3 years. The position is associated with the research group of Dr. Vivi Ann Flørenes, Department of Pathology, Oslo University Hospital (OUS), The Radium Hospital, in close collaboration with the groups of Professor Gunhild Mælandsmo, Head of Department of Tumor Biology, Institute for Cancer Research, The Radium Hospital, OUS and Dr. Jon Amund Kyte, Head of Department of Clinical Cancer Research.
The melanoma research group headed by Dr. Flørenes has for many years investigated how to improve prediction of clinical outcome and therapy responses in metastatic melanomas. Norway is on the top list of melanoma incidences and deaths per inhabitant.   Although management of metastatic melanomas has experienced a paradigm shift in recent years with approval of inhibitors of mutated BRAF and immune checkpoint inhibitors, a substantial number of patients will not benefit from these treatments.  Thus, strategies to identify patients on risk to relapse and stratification for personal treatment plans have our highest research priority.

Job description
The Postdoc will work on a project to characterize the tumor’s microenvironment combined with molecular profiling and ex vivo assessment of response. CyTOF and multicolor flow cytometry as well as NanoString technology will be applied to identify biomarkers of importance. Likewise, an ex vivo assay to screen patients own tumor tissue for treatment responses will be applied and optimized to be applicable to immune therapy. 

Qualifications and Personal Skills

Applicants must hold a doctoral degree (PhD) in life science or medicine. We seek a highly motivated candidate that is able to work independently as well as in a team. The applicant must speak and write English fluently. Experience with advanced molecular technics such as Flow cytometry (CyTOF) and gene expression analyses (NanoString) will be considered as an advantage. The successful candidate should also be familiar with basic cell biology technics such as culturing of cells, transfections and western blot analysis. In addition the applicant should be familiar with handling big data sets (statistics, bioinformatics) and having skills in immunology.

The application should include
The application should be written in English
Application letter summarizing the candidate’s previous career and a description of how the candidate will fill the role as a successful candidate
CV summarizing education, positions held, and details of academic work
List of publications (don’t send publications)
Copies of educational certificates and transcripts of records
Names and contact details of 2-3 references (name, relation to candidate , email and telephone number)